Compositions and methods of treatment of drug resistant cancers

摘要: Time-staggered inhibition of EGFR, in combination with DNA damaging agents, is a useful therapeutic strategy for treating cancers, particularly drug resistant cancers such as subset triple-negative tumors, those high basal levels phosphorylated EGFR. The staggered therapy was also demonstrated to be applicable other types especially lung which contain either wild-type EGFR or mutations within itself. dramatically sensitizes cancer cells damage if the drugs are given sequentially, but not simultaneously. first must administered dosage and period time sufficient dynamic network rewiring an oncogenic signature maintained by active signaling unmask apoptotic process that involves activation caspase-8.