Inhibitor of neuronal connectivity linked to schizophrenia susceptibility and cognitive dysfunction
作者： Maria Karayiorgou , Joseph A. Gogos , Bin Xu
DOI:
关键词: Neuroscience 、 Small hairpin RNA 、 Cognition 、 Psychology 、 A protein 、 Schizophrenia (object-oriented programming)
摘要: The present invention relates to methods and compositions for enhancing neuronal connectivity. It is based, at least in part, on the discovery of a protein, termed "Mirta22," that inhibits formation structures which create connections between neurons. further inhibiting Mirta22 activity by short hairpin RNA was able restore these structures. discovered experiments relating 22q 11 microdeletions, have been linked schizophrenia. Accordingly, provides treating schizophrenia comprising administering an agent activity. may also be used treatment other disorders would benefit from enhanced neural connectivity, including learning memory disorders.
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