VIP and PACAP receptors coupled to adenylyl cyclase in human lung cancer: a study in biopsy specimens.
作者： Rebeca Busto , Juan C. Prieto , Guillermo Bodega , José Zapatero , Luis Fogué
DOI: 10.1016/S0196-9781(03)00058-5
关键词: Lung cancer 、 Vasoactive intestinal peptide 、 Adenylate kinase 、 Internal medicine 、 Neuropeptide 、 Endocrinology 、 Adenylyl cyclase 、 G protein-coupled receptor 、 Cell growth 、 Receptor 、 Chemistry
摘要: Abstract Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are important neuropeptides in the control of lung physiology. Both these commonly bind to specific G protein coupled receptors named VPAC 1 -R 2 -R, PAC (with higher affinity for PACAP). VIP PACAP have been implicated cell proliferation tumor growth. This study examined presence human cancer samples, as well functionality adenylyl cyclase (AC) stimulated by both peptides. Results from RT-PCR immunoblot experiments showed expression -, - samples. Immunohistochemical studies receptors. These were positively AC, but enzyme activity was impaired compared normal lung. There no changes Gα s or i levels. Present results contribute a better knowledge VIP/PACAP actions support interest development analogues with therapeutic roles.
elsevier.com
sci-hub.se 参考文章(35)
[Pituitary adenylate cyclase-activating polypeptide]. Annales D Endocrinologie. ,vol. 59, pp. 364- 405 ,(2003) , 10.1007/978-1-4615-0243-2
Masaru Ogasawara, Jun Murata, Yukio Kamitani, Kazuko Hayashi, Ikuo Saiki, Inhibition by vasoactive intestinal polypeptide (VIP) of angiogenesis induced by murine Colon 26-L5 carcinoma cells metastasized in liver. Clinical & Experimental Metastasis. ,vol. 17, pp. 283- 291 ,(1999) , 10.1023/A:1006648402164
Terry W. Moody, Louis Y. Korman, Desmond N. Carney, Marc L. Citron, Secretin/vasoactive intestinal peptide-stimulated secretion of bombesin/gastrin releasing peptide from human small cell carcinoma of the lung Cancer Research. ,vol. 46, pp. 1214- 1218 ,(1986)
Michael Birrer, Illana Gozes, Sonia Jakowlew, Mati Fridkin, Yehoshua Gozes, Toyoaki Hida, Terry W. Moody, Jean C. Reubi, Hasan Zia, Breast cancer growth is inhibited by vasoactive intestinal peptide (VIP) hybrid, a synthetic VIP receptor antagonist. Cancer Research. ,vol. 56, pp. 3486- 3489 ,(1996)
P de Cremoux, C Gespach, F Calvo, W Bawab, Pharmacology, Molecular Identification and Functional Characteristics of Vasoactive Intestinal Peptide Receptors in Human Breast Cancer Cells Cancer Research. ,vol. 48, pp. 5079- 5083 ,(1988)
Mirela Fagarasan, David H. Coy, Terry W. Moody, Kamil Bitar, Steve A. Wank, Joe R. Pisegna, Farah Zia, Pituitary adenylate cyclase activating peptide receptors regulate the growth of non-small cell lung cancer cells. Cancer Research. ,vol. 55, pp. 4886- 4891 ,(1995)
James A. Waschek, Stephen A. Wank, Anthony J. Harmar, Illana Gozes, Laurent Journot, Marc Laburthe, Akira Arimura, Patrick Robberecht, Joseph R. Pisegna, Stephen R. Rawlings, Sunil P. Sreedharan, Sami I. Said, International Union of Pharmacology. XVIII. Nomenclature of Receptors for Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Pharmacological Reviews. ,vol. 50, pp. 265- 270 ,(1998)
K. Maruno, A. Absood, S. I. Said, Vasoactive intestinal peptide inhibits human small-cell lung cancer proliferation in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 14373- 14378 ,(1998) , 10.1073/PNAS.95.24.14373
Marchessini Casibang, Sally Purdom, Sonia Jakowlew, Len Neckers, Farah Zia, Pazit Ben-Av, Tim Hla, Liang You, David M Jablons, Terry W Moody, None, Prostaglandin E2 and vasoactive intestinal peptide increase vascular endothelial cell growth factor mRNAs in lung cancer cells. Lung Cancer. ,vol. 31, pp. 203- 212 ,(2001) , 10.1016/S0169-5002(00)00168-9
Elizabeth H Hammond, Robert L Yowell, Robert L Flinner, Neuroendocrine carcinomas: Role of immunocytochemistry and electron microscopy Human Pathology. ,vol. 29, pp. 1367- 1371 ,(1998) , 10.1016/S0046-8177(98)90004-1