Therapeutic methods for muscular or neuromuscular disorders
作者： Xiangping Li , Lisa-Anne Whittemore
DOI:
关键词: Physical therapy 、 Medicine 、 Bioinformatics
摘要: The disclosure provides methods for treating neuromuscular disorders in mammals. disclosed include administering therapeutically effective amounts of a GDF-8 inhibitor and corticosteroid to subject susceptible to, or having, disorder, so as maintain desirable levels muscle function.
lens.org 参考文章(152)
Stokes H, Parker W, Doerr L, Ashmore Cr, Comparative aspects of muscle fiber types in fetuses of the normal and "double-muscled" cattle. Growth. ,vol. 38, pp. 501- 506 ,(1974)
E Casas, J W Keele, S D Shackelford, M Koohmaraie, T S Sonstegard, T P Smith, S M Kappes, R T Stone, Association of the muscle hypertrophy locus with carcass traits in beef cattle. Journal of Animal Science. ,vol. 76, pp. 468- 473 ,(1998) , 10.2527/1998.762468X
Seungkwon You, Mohamed El Halawani, Use of passive myostatin immunization ,(2001)
James F. Tobin, Combination therapy for diabetes, obesity and cardiovascular diseases using GDF-8 inhibitors ,(2005)
S T Lee, E Kessler, D S Greenspan, Analysis of site-directed mutations in human pro-alpha 2(I) collagen which block cleavage by the C-proteinase. Journal of Biological Chemistry. ,vol. 265, pp. 21992- 21996 ,(1990) , 10.1016/S0021-9258(18)45837-1
Kunihiro Tsuchida, Wylie W. Vale, Lawrence W. Mathews, Methods of screening for compounds that bind to activin receptor ,(2000)
Alexandra McPherron, Se-Jin Lee, Methods to identify growth differentiation factor (GDF) binding proteins ,(1997)
Steven Dickman, Gene Mutation Provides More Meat on the Hoof Science. ,vol. 277, pp. 1922- 1923 ,(1997) , 10.1126/SCIENCE.277.5334.1922
Steen Klysner, Soeren Mouritsen, Torben Halkier, Method for down-regulating GDF-8 activity ,(2000)
Alexandra C. McPherron, Ann M. Lawler, Se-Jin Lee, Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11 Nature Genetics. ,vol. 22, pp. 260- 264 ,(1999) , 10.1038/10320