Technology Insight: vaccine therapy for prostate cancer.

摘要: Despite the amount of research that has gone into producing vaccines against cancer, these have yet to show clinical benefit. This article by J Vieweg and Dannull reviews current status vaccination strategies for prostate gives an update on different stages in their development. The lack effective therapies advanced cancer mandates continued development alternative treatment strategies. Insights regulation immune responses malignant process facilitated emergence new immune-based strategies, currently under investigation trials. Like other forms targeted therapy, hold promise achieving control without inducing overt toxicity. Many at phases been tested Vaccination consideration include: immunization with defined antigenic preparations such as synthetic peptides, proteins or plasmid DNA; antigen-loaded dendritic cells; manipulated tumor viral vectors engineered express immunogenic genes. Although underlying mechanisms may vary, all share common goal eliciting tumor-associated antigens enhancing otherwise weak antitumor response patient. Unlocking therapeutic potential will require a thorough understanding cellular molecular modulate response. In this review, we provide overview vaccine-based discuss action, relevant trial data.