Tumor Antigen-Specific Monoclonal Antibody-Based Immunotherapy, Cancer Initiating Cells and Disease Recurrence
作者： Yangyang Wang , Francesco Sabbatino , Ling Yu , Elvira Favoino , Xinhui Wang
DOI: 10.1007/978-1-4614-7654-2_2
关键词: Monoclonal antibody 、 Cancer research 、 Cancer 、 Osteosarcoma 、 Pancreatic cancer 、 Head and neck cancer 、 Immunotherapy 、 Internal medicine 、 Tumor antigen 、 Oncology 、 Breast cancer 、 Medicine
摘要: Immunotherapy with tumor antigen (TA)-specific monoclonal antibody (mAb) has been shown to be effective in the treatment of several types cancer. However, its efficacy is limited by lack response some treated patients and disease recurrence. In this chapter, following a short description characteristics cancer initiating cells (CICs) markers used for their identification various cancer, we will provide vitro evidence suggest that recurrence caused eradication CICs TA-specific mAb-based immunotherapy. addition, describe potential strategies overcome resistance mechanism which major obstacle successful application
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