Reference values for local arterial stiffness. Part B

摘要: OBJECTIVE: Carotid-femoral pulse wave velocity (PWV) is considered the gold standard measure of arterial stiffness, representing mainly aortic stiffness. As compared with elastic carotid and aorta, more muscular femoral artery may be differently associated cardiovascular risk factors (CV-RFs), or, as shown in a recent study, provide additional predictive information beyond carotid-femoral PWV. Still, clinical application hampered by absence reference values. Therefore, our aim was to establish age sex-specific values for stiffness healthy individuals investigate associations CV-RFs. METHODS: Femoral distensibility coefficient, inverse calculated ratio relative diastolic-systolic distension (obtained from ultrasound echo-tracking) pressure among 5069 (49.5% men, range: 15-87 years). Individuals without disease (CVD), CV-RFs medication use (n = 1489; 43% men) constituted subpopulation used equations percentiles coefficient across age. RESULTS: In total population, Z-scores were independently BMI, mean (MAP) high-density lipoprotein (HDL) cholesterol ratio. Standardized βs, men women, respectively, -0.18 [95% confidence interval (95% CI) -0.23 -0.13] -0.19 (-0.23 -0.14) BMI; -0.13 (-0.18 -0.08) -0.05 (-0.10 -0.01) MAP; -0.07 (-0.11 -0.02) -0.16 (-0.20 -0.11) total-to-HDL CONCLUSION: young middle-aged normal does not change substantially up sixth decade. related metabolic are