Proteomics: methodologies and applications in oncology
DOI: 10.1016/J.SEMRADONC.2007.10.008
关键词: Proteomics methods 、 Proteome 、 Computational biology 、 Cellular proteins 、 In patient 、 Function (engineering) 、 Modalities 、 Genomic databases 、 Biology 、 Proteomics
摘要: Few technological developments have created as much excitement and skepticism proteomics over their potential to change clinical diagnostic prognostic procedures. Proteomics concerns itself with the characterization function of all cellular proteins, ultimate determinants function. As such, it represents end result mechanisms gene regulation thus offers tremendous for characterizing biology. In same way what has occurred genome, scientific community is coming grips fact that proteome, although enormously complex, finite. It conceivable we will learn identity possible including posttranslational modifications. The rate protein discovery continues accelerate in large part because improvements mass spectrometry-based technologies coupled improved genomic databases bioinformatic tools. addition, there reason believe on verge moving from a methodology requires repeated proteome "discovery" one can more systematically profile proteomes. This review discusses current proteomic-based efforts scientists move them into clinic use patients treated radiotherapy other modalities.
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