Transcriptional and Post-Transcriptional Mechanisms of the Development of Neocortical Lamination.

摘要: The neocortex is a laminated brain structure that the seat of higher cognitive capacity and responses, long-term memory, sensory emotional functions, voluntary motor behavior. Proper lamination requires progenitor cells give rise to neuron, immature neuron can migrate away from its mother cell past other cells, finally take place adopt mature identity characterized by connectivity gene expression; thus proceeds through three steps: genesis, migration, maturation. Each neocortical layer contains pyramidal neurons share specific morphological molecular characteristics stem their prenatal birth date. Transcription factors are dynamic proteins because cohort downstream they regulate. RNA-binding no less dynamic, play important roles in every step mRNA processing. Indeed, recent screens have uncovered post-transcriptional mechanisms as being integral regulatory development. Here, we summarize major aspects laminar development, emphasizing transcriptional mechanisms, with aim spurring increased understanding study intricacies.