Control and Function of the Homeostatic Sleep Response by Adenosine A1 Receptors

摘要: During sleep, the mammalian CNS undergoes widespread, synchronized slow-wave activity (SWA) that directly varies with previous waking duration (Borbely, 1982; Dijk et al., 1990). When sleep is restricted, an enhanced SWA response follows in next period. The enhancement of associated improved cognitive performance (Huber 2004), but it unclear either how or whether needed to maintain normal performance. A conditional, knock-out adenosine receptor, AdoA1R gene, shows selective attenuation rebound restricted not affected. restriction, wild phenotype animals express a and working memory task. However, only show reduced they also fail function, although this function when restricted. Thus, activation for SWA, reduced, there failure suggesting functional role homeostasis.