HighLevelsofCreExpressioninNeuronalProgenitorsCause DefectsinBrainDevelopmentLeadingtoMicroencephaly andHydrocephaly

作者： K. Betz , AlessandroE . Vercelli

DOI:

关键词: Progenitor cell 、 Cancer research 、 Hydrocephalus 、 Nestin 、 Molecular biology 、 Biology 、 Cre recombinase 、 Nuclear localization sequence 、 Brain development

摘要: Hydrocephalus is a common and variegated pathology often emerging in newborn children after genotoxic insults during pregnancy(HicksandD’Amato,1980).Crerecombinaseisknowntohavepossibletoxiceffectsthatcancompromisenormalcellcycleandsurvival.Hereweshow,byusingthreeindependentnestinCretransgeniclines,thathighlevelsofCrerecombinaseexpressionintothenucleusofneuronal progenitors can compromise normal brain development. The transgenics analyzed are the nestin Cre Balancer (Bal1) line,expressing recombinase with nuclear localization signal, two CreER

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HighLevelsofCreExpressioninNeuronalProgenitorsCause DefectsinBrainDevelopmentLeadingtoMicroencephaly andHydrocephaly

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HighLevelsofCreExpressioninNeuronalProgenitorsCause DefectsinBrainDevelopmentLeadingtoMicroencephaly andHydrocephaly

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