Zinc Oxide Nanoparticles Cytotoxicity and Release from Newly Formed PMMA-ZnO Nanocomposites Designed for Denture Bases.

摘要: The goal of the study was to investigate level zinc oxide nanoparticles (ZnO NPs) release from polymethyl methacrylate (PMMA)–ZnO nanocomposites (2.5%, 5%, and 7.5% w/w), as well ZnO NPs layer produced on pure PMMA, impact achieved final concentration cytotoxicity, before potential use an alternative material for denture bases. released aqueous solution Zn2+ ions assessed using optical emission spectrometry with inductively coupled plasma (ICP-OES). In control group (pure PMMA), mean 0.074 mg/L individual at concentrations 2.5%, 2.281 mg/L, 2.143 3.512 respectively. median PMMA 4.878 mg/L. addition, in vitro cytotoxicity against human HeLa cell line determined through reduction 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) dye. studies demonstrate that up 20 have no adverse effect cells. When compared cytotoxic NPs, it can be expected dental prostheses oral cavity environment will host