Nanoparticles And Human Saliva: A Step Towards Drug Delivery Systems For Dental And Craniofacial Biomaterials.
作者： Rafal Pokrowiecki , Jacek Wojnarowicz , Tomasz Zareba , Iwona Koltsov , Witold Lojkowski
DOI: 10.2147/IJN.S221608
关键词: Drug delivery 、 Kinetics 、 Saliva 、 Nuclear chemistry 、 Solvothermal synthesis 、 Nanomaterials 、 Antibacterial activity 、 Chemistry 、 Nanoparticle 、 Destabilisation
摘要: Aim The aims of this study were to investigate new nano-formulations based on ZnO and Ag nanoparticle (NP) compounds when used against clinical strains oral gram-positive gram-negative bacteria, examine the stability behaviour nano-formulation mixtures in saliva different compositions NPs, NPs ZnO+x·Ag NPs. Methods: with without nanosilver obtained by microwave solvothermal synthesis. Then, antibacterial activity was evaluated bacteria isolated from human saliva. Behavior solutions control (artificial deionized water). Results statistically compared. NP had an average size 30±3 nm, while commercial 55±5 nm. suspensions displayed differing activities kinetics destabilisation processes, depending composition fluid types. Conclusion present showed that all significant high over 24 h analyses. agglomeration processes can be reversible.
sci-hub.se 参考文章(76)
Witold Lojkowski, Rafal Pokrowiecki, Tomasz Zareba, Agnieszka Opalińska, Jacek Wojnarowicz, Agnieszka Mielczarek, Stefan Tyski, Marcin Majkowski, Evaluation of biocidal properties of silver nanoparticles against cariogenic bacteria Medycyna doświadczalna i mikrobiologia. ,vol. 65, pp. 197- 206 ,(2013)
Marek Jałbrzykowski, Joanna Kolmas, Edyta Andrysewicz, Joanna Mystkowska, Jan R Dąbrowski, Rafał Olchowik, Influence of artificial saliva compositions on tribological characteristics of Ti-6Al-4V implant alloy. Acta of Bioengineering and Biomechanics. ,vol. 14, pp. 71- 79 ,(2012)
Marina E Vance, Todd Kuiken, Eric P Vejerano, Sean P McGinnis, Michael F Hochella, David Rejeski, Matthew S Hull, Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory. Beilstein Journal of Nanotechnology. ,vol. 6, pp. 1769- 1780 ,(2015) , 10.3762/BJNANO.6.181
R.H Müller, C Jacobs, O Kayser, Nanosuspensions as particulate drug formulations in therapy: Rationale for development and what we can expect for the future Advanced Drug Delivery Reviews. ,vol. 47, pp. 3- 19 ,(2001) , 10.1016/S0169-409X(00)00118-6
Gerard H. Bode, Karin E. Pickl, Maria Sanchez-Purrà, Berta Albaiges, Salvador Borrós, Andy J. G. Pötgens, Christoph Schmitz, Frank M. Sinner, Mario Losen, Harry W. M. Steinbusch, Hans-Georg Frank, Pilar Martinez-Martinez, , Detection of Peptide-Based Nanoparticles in Blood Plasma by ELISA PLOS ONE. ,vol. 10, pp. e0126136- ,(2015) , 10.1371/JOURNAL.PONE.0126136
Limin Wei, Xiaoli Feng, Aijie Chen, Yanli Zhang, Jianfeng Wang, Longquan Shao, Application of dental nanomaterials: potential toxicity to the central nervous system International Journal of Nanomedicine. ,vol. 10, pp. 3547- 3565 ,(2015) , 10.2147/IJN.S79892
Thomas L. Moore, Laura Rodriguez-Lorenzo, Vera Hirsch, Sandor Balog, Dominic Urban, Corinne Jud, Barbara Rothen-Rutishauser, Marco Lattuada, Alke Petri-Fink, Nanoparticle colloidal stability in cell culture media and impact on cellular interactions Chemical Society Reviews. ,vol. 44, pp. 6287- 6305 ,(2015) , 10.1039/C4CS00487F
Christian P. Schultz, M.Khalique Ahmed, Colin Dawes, Henry H. Mantsch, Thiocyanate Levels in Human Saliva: Quantitation by Fourier Transform Infrared Spectroscopy Analytical Biochemistry. ,vol. 240, pp. 7- 12 ,(1996) , 10.1006/ABIO.1996.0323
M. Boström, D. R. M. Williams, B. W. Ninham, Specific Ion Effects: Why DLVO Theory Fails for Biology and Colloid Systems Physical Review Letters. ,vol. 87, pp. 168103- ,(2001) , 10.1103/PHYSREVLETT.87.168103
Justin M. Zook, Robert I. MacCuspie, Laurie E. Locascio, Melissa D. Halter, John T. Elliott, Stable nanoparticle aggregates/agglomerates of different sizes and the effect of their size on hemolytic cytotoxicity Nanotoxicology. ,vol. 5, pp. 517- 530 ,(2011) , 10.3109/17435390.2010.536615