The Central Nervous System and Immune Responses: Conditioned Immunopharmacologic Effects

摘要: ABSTRACT Behavioral conditioning represents one of several converging lines research indicating that central nervous system processes are capable influencing immune responses. Several studies described in which an illness-induced taste aversion paradigm was used to modify immunologic reactivity. A neutral stimulus (saccharin) first paired with the injection cyclophosphamide, immunosuppressive drug. Experimental (conditioned) animals were reexposed saccharin when immunogenic stimulation subsequently introduced. Relative conditioned not and non-conditioned placebo-treated animals, experimental rats and/or mice displayed a typical also showed attenuated antibody response T-cell dependent independent antigens diminished graft-versus-host response.