Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers.
作者： Shamsi D. Raeissi , Ismael J. Hidalgo , Juan Segura‐Aguilar , Per Artursson
关键词: Efflux 、 Biochemistry 、 Terfenadine 、 Cytochrome P450 、 Biology 、 Metabolism 、 CYP3A 、 Cell 、 Intestinal epithelium 、 Cell Clone
摘要: Purpose. To further characterize cytochrome P450 (CYP) and P-glyco-protein (Pgp) expression in monolayers of the Caco-2 cell clone TC7, a culture model human intestinal epithelium. study interplay between CYP3A Pgp as barriers to drug absorption TC7 cells using terfenadine its metabolites substrates.
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