Modern Methods of Drug Discovery
作者： Rolf Hilgenfeld , Alexander Hillisch
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摘要: 1 Modern methods of drug discovery: An introduction.- 2 Proteomics.- 3 Bioinformatics.- 4 High-throughput screening technologies.- 5 Natural products for lead identification: Nature is a valuable resource providing tools.- 6 Combinatorial chemistry: Mixture-based combinatorial libraries acyclic and heterocyclic compounds from amino acids short peptides.- 7 Computational approaches towards the quantification molecular diversity design compound libraries.- 8 The role protein 3D-structures in discovery process.- 9 NMR-based discovery.- 10 Structure-based 11 3D QSAR modern design.- 12 Physicochemical concepts 13 Computer-aided prediction toxicity metabolism.
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Han Waterbeemd, Physicochemical concepts in drug design. EXS. pp. 243- 257 ,(2003) , 10.1007/978-3-0348-7997-2_12
Susanne Grabley, Isabel Sattler, Natural products for lead identification: nature is a valuable resource for providing tools. EXS. pp. 87- 107 ,(2003) , 10.1007/978-3-0348-7997-2_5
Christopher Wills, Phylogenetic Analysis and Molecular Evolution Biocomputing#R##N#Informatics and Genome Projects. pp. 175- 201 ,(1994) , 10.1016/B978-0-08-092596-7.50009-5
Claudio Dalvit, Philipp Floersheim, Mauro Zurini, Armin Widmer, Use of organic solvents and small molecules for locating binding sites on proteins in solution Journal of Biomolecular NMR. ,vol. 14, pp. 23- 32 ,(1999) , 10.1023/A:1008378929578
J. Devillers, W. Karcher, Practical applications of quantitative structure-activity relationships (QSAR) in environmental chemistry and toxicology Kluwer Acedemic. ,(1990)
Bengt Persson, Patrick Argos, PREDICTION OF MEMBRANE PROTEIN TOPOLOGY UTILIZING MULTIPLE SEQUENCE ALIGNMENTS Journal of Protein Chemistry. ,vol. 16, pp. 453- 457 ,(1997) , 10.1023/A:1026353225758
Robert H. Knopp, Drug treatment of lipid disorders The New England Journal of Medicine. ,vol. 341, pp. 498- 511 ,(1999) , 10.1056/NEJM199908123410707
Jean Garnier, Jean-François Gibrat, Barry Robson, GOR method for predicting protein secondary structure from amino acid sequence. Methods in Enzymology. ,vol. 266, pp. 540- 553 ,(1996) , 10.1016/S0076-6879(96)66034-0
Burkhard Rost, PHD: predicting one-dimensional protein structure by profile-based neural networks. Methods in Enzymology. ,vol. 266, pp. 525- 539 ,(1996) , 10.1016/S0076-6879(96)66033-9
J.-F. Gibrat, J. Garnier, B. Robson, Further developments of protein secondary structure prediction using information theory: New parameters and consideration of residue pairs☆ Journal of Molecular Biology. ,vol. 198, pp. 425- 443 ,(1987) , 10.1016/0022-2836(87)90292-0