Natural products for lead identification: nature is a valuable resource for providing tools.

作者: Susanne Grabley , Isabel Sattler

DOI: 10.1007/978-3-0348-7997-2_5

关键词: Natural productNatural (archaeology)Resource (biology)Biochemical engineeringLead (geology)Identification (biology)EngineeringNatural resource economicsDrug discovery

摘要: About 30% of drugs on the worldwide market are natural products or derived from products. A similar ratio accounts for clinical candidates currently under development. Though recombinant proteins and peptides account an increasing volume, superiority low-molecular mass compounds in human diseases therapy remains undisputed mainly due to more favorable compliance bioavailability properties.

参考文章(27)
D. H. Attaway, O. R. Zaborsky, Marine biotechnology. Volume 1. Pharmaceutical and bioactive natural products. Plenum Publishing Corporation. ,(1993)
Ralf Thiericke, Susanne Grabley, Drug Discovery from Nature ,(2000)
Eric M. Gordon, James F. Kerwin, Combinatorial chemistry and molecular diversity in drug discovery Wiley. ,(1998)
Jürgen Rohr, Combinatorial Biosynthesis–An Approach in the Near Future? Angewandte Chemie International Edition in English. ,vol. 34, pp. 881- 885 ,(1995) , 10.1002/ANIE.199508811
Isabel Sattler, Susanne Grabley, Ralf Thiericke, Structure Modification via Biological Derivatization Methods ChemInform. ,vol. 30, ,(1999) , 10.1002/CHIN.199930300
Michael Reggelin, Volker Brenig, Reinhard Welcker, Towards polyketide libraries — II: Synthesis of chiral aracemic di- and triketides on a solid support Tetrahedron Letters. ,vol. 39, pp. 4801- 4804 ,(1998) , 10.1016/S0040-4039(98)00924-1
Susanne Grabley, Ralf Thiericke, Access to Structural Diversity via Chemical Screening ChemInform. ,vol. 32, ,(2001) , 10.1002/CHIN.200112296
Corinna Koch, Thomas Neumann, Der Naturstoff-Pool-neuer Ansatz für die Wirkstoffsuche Nachrichten aus Chemie, Technik und Laboratorium. ,vol. 45, pp. 16- 18 ,(1997) , 10.1002/NADC.19970450109