Human umbilical cord blood cell grafts for brain ischemia.

摘要: Irreversible and permanent damage develop immediately adjacent to the region of reduced cerebral blood perfusion in stroke patients. Currently, proven thrombolytic treatment for stroke, tissue plasminogen activator, is only effective when administered within 3 h after stroke. These disease characteristics should be taken under consideration developing any therapeutic intervention designed widen narrow range, especially cell-based therapy. Over past several years, our group others have characterized potential human umbilical cord cells other neurological disorders using vitro vivo models focusing on cells' ability differentiate into nonhematopoietic including neural lineage, as well their produce neurotrophic factors modulate immune inflammatory reaction. Rather than conventional cell replacement mechanism, we advance alternative pathways graft-mediated brain repair involving effects resulting from release various growth that afford survival, angiogenesis, anti-inflammation. Eventually, these multiple protective restorative grafts may interdependent act harmony promoting benefits