Nutritional factors and gastric cancer in Zhoushan Islands, China

作者: Jiong-Liang Qiu

DOI: 10.3748/WJG.V11.I28.4311

关键词: PhysiologyPolyunsaturated fatGerontologyCancerSaturated fatVitaminAscorbic acidMicronutrientCalorieOdds ratio

摘要: AIM: To investigate the association between nutrient intakes and high incidence rate of gastric cancer among residents in Zhoushan Islands. METHODS: A frequency-matched design case-control study was used during survey on dietary factors Islands, China. total 103 cases diagnosed 2001 were included 133 controls randomly selected from Islands. food frequency questionnaire specifically designed for Chinese pattern to collect information intake. computerized database other relative each participant completed. Total calories 15 nutrients calculated according composition table their adjusted odds ratios (ORs) 95% confidence intervals (CIs) estimated by gender using unconditional logistic regression models. RESULTS: High protein, saturated fat, cholesterol observed with increased risk particularly males (ORQ4 vs Q1 10.3, 3.24, 2.76 respectively). While carbohydrate a significant high-risk = 14.8; P linear trend 0.024) females. Regardless gender, reported significantly higher daily intake sodium mainly salts. As vitamins C, an inversed GC found. Baseline characteristics participants briefly described. CONCLUSION: The findings this confirm role diet-related exposure etiology point view epidemiology. An is associated sodium, while consumption polyunsaturated vitamin ascorbic acid may have protective effect against cancer.

参考文章(29)
C Guo, M Wang, M Li, [A case-control study on the dietary risk factors of upper digestive tract cancer]. Chinese journal of epidemiology. ,vol. 20, pp. 95- 97 ,(1999)
Domenico Palli, Epidemiology of gastric cancer: an evaluation of available evidence. Journal of Gastroenterology. ,vol. 35, pp. 84- 89 ,(2000)
Domenico Palli, Antonio Russo, Adriano Decarli, Dietary patterns, nutrient intake and gastric cancer in a high-risk area of Italy. Cancer Causes & Control. ,vol. 12, pp. 163- 172 ,(2001) , 10.1023/A:1008970310963
Piet A van den Brandt, Anita AM Botterweck, R Alexandra Goldbohm, None, Salt intake, cured meat consumption, refrigerator use and stomach cancer incidence: a prospective cohort study (Netherlands). Cancer Causes & Control. ,vol. 14, pp. 427- 438 ,(2003) , 10.1023/A:1024979314124
Sanford M. Dawsey, Dennis W. Buckman, Chung S. Yang, William J. Blot, Zhi‐Wei Dong, Philip R. Taylor, Steven D. Mark, Christian C. Abnet, You‐Lin Qiao, Prospective study of serum retinol, β-carotene, β-cryptoxanthin, and lutein/zeaxanthin and esophageal and gastric cancers in China Cancer Causes & Control. ,vol. 14, pp. 645- 655 ,(2003) , 10.1023/A:1025619608851
Charles A. Dangler, James G. Fox, Nancy S. Taylor, Theodore J. Koh, Timothy C. Wang, Amy King, High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL/6 mice. Cancer Research. ,vol. 59, pp. 4823- 4828 ,(1999)
Kristi A. Steinmetz, John D. Potter, Vegetables, fruit, and cancer. II. Mechanisms. Cancer Causes & Control. ,vol. 2, pp. 427- 442 ,(1991) , 10.1007/BF00054304
Lizbeth López‐Carrillo, Malaquías López‐Cervantes, Mary H Ward, Jaime Bravo‐Alvarado, Armando Ramírez‐Espitia, None, Nutrient intake and gastric cancer in Mexico International Journal of Cancer. ,vol. 83, pp. 601- 605 ,(1999) , 10.1002/(SICI)1097-0215(19991126)83:5<601::AID-IJC5>3.0.CO;2-6
Anna Mia Ekström, Mauro Serafini, Olof Nyrén, Lars-Erik Hansson, Weimin Ye, Alicja Wolk, Dietary antioxidant intake and the risk of cardia cancer and noncardia cancer of the intestinal and diffuse types: a population-based case-control study in Sweden. International Journal of Cancer. ,vol. 87, pp. 133- 140 ,(2000) , 10.1002/1097-0215(20000701)87:1<133::AID-IJC20>3.0.CO;2-E
Helmut Bartsch, Hiroshi Ohshima, Brigitte Pignatelli, Inhibitors of endogenous nitrosation. Mechanisms and implications in human cancer prevention. Mutation Research. ,vol. 202, pp. 307- 324 ,(1988) , 10.1016/0027-5107(88)90194-7