摘要: Despite a dramatic reduction in incidence and mortality rates, gastric cancer (GC) is still one of the most common malignant neoplasias worldwide. Surgical medical treatments have not substantially improved during last decades, large-scale early diagnosis programs proven feasible only high-risk country, Japan. A large number studies indicated that salted, smoked, pickled, preserved foods (rich salt, nitrite, preformed N-nitroso compounds) are associated with an increased risk GC. In contrast, strong evidence has been provided high consumption fresh fruit raw vegetables intake antioxidants reduced Domestic refrigeration salt considered to play role explaining decreasing temporal trend geographical patterns Familial factors suspected GC susceptibility, recently germ line mutations E-cadherin gene were identified few families. Evidence positive association between Helicobacter pylori infection by prospective overall suggest two- threefold increase risk. Randomized intervention on H. eradication its effects predisposing conditions (atrophic gastritis intestinal metaplasia) progress represent priority for epidemiological research view potential preventive applications. Overall, it evident several (including diet, individual susceptibility infection) interact complex multifactorial process, leading over long period time
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