Genetic variations in the mTOR gene contribute toward gastric adenocarcinoma susceptibility in an Eastern Chinese population.

摘要: BACKGROUND AND AIM Genetic variants in the mammalian target of rapamycin (mTOR) gene have become an interesting topic for study genetic susceptibility to cancer, but their associations with risk gastric cancer not been fully investigated. MATERIALS METHODS In a hospital-based case-control 1002 patients and 1003 cancer-free controls, we genotyped four potentially functional single nucleotide polymorphisms (SNPs) (rs1034528G>C, rs17036508T>C, rs3806317A>G, rs2295080T>G) mTOR assessed using univariate multivariate logistic regression analyses. We also used multifactorial dimension reduction analysis explore possible interactions false-positive report probabilities assess significant findings. RESULTS found that rs1034528 CG/CC rs3806317 GA/GG variant genotypes were associated increased under dominant model (adjusted odds ratio=1.27 1.22, respectively). combined all SNPs investigation, 3-4 had significantly ratio=1.46, 95% confidence interval=1.19-1.79) compared those 0-2 genotypes. Stratified indicated this was more pronounced subgroups men, never-smokers, never-drinkers, clinical stages III+IV. The suggested some evidence between other factors cancer. CONCLUSION These findings suggest may individually or collectively contribute Larger studies diverse ethnic populations are warranted validate our