Relatives of prostate cancer patients have an increased risk of prostate and stomach cancers: a population-based, cancer registry study in Finland.

摘要: Objective: Five to ten percent of prostate cancers may be caused by inherited genetic defects. In order explore the nature cancer risks in genetically homogeneous Finnish population, we investigated incidence and other first-degree relatives patients linking population-based parish records on with Cancer Registry (FCR) data. Methods: The study population was composed two groups diagnosed Finland during 1988–1993: (1) all early-onset (≤60years) (n=557) from entire country, (2) a sample (n=989) at an age >60years. A total 11,427 were identified through records, their determined based 299,970 person-years. Standardized ratios (SIR) calculated expected rates general population. Results: SIR increased both Cohort 1 (2.5, 95% CI 1.9–3.2) 2 (1.7, 1.4–2.1). risk high for early age, then leveled off median diagnosis (70–79 years). However, ≥80years again statistically significantly elevated (SIR 1.8, 1.3–2.6), suggesting contribution factors also late onset. Gastric only type among relatives. Increased gastric seen male highest detected 55 years or less 5.0, 2.8–8.2). Conclusions: Our indicates that hereditary play important role development men younger older ages. This finding is relevant context our observations HPCX (hereditary susceptibility locus Xq27-28) linkage found exclusively families association has not been reported previously, reflect effects novel predisposition locus, which increases these common tumor types.