Genetic susceptibility to prostate cancer: a review
作者： Bas A. J. Verhage
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摘要: A genetic component in prostate cancer has been recognized since decades. Through numerous epidemiological and molecular biological studies, much evidence accumulated favor of a significant but heterogeneous hereditary (PCa) susceptibility. Since the mapping high-penetrant PCa susceptibility locus at 1q24–25, attention paid to identification genes. So far, seven loci have mapped, three these loci, genes cloned mutations identified. Yet their role sporadic disease is still under debate probably very modest. Although research on improved our knowledge etiology disease, lot questions remain unanswered. Here, we aim review field problems that are encountered with this research.
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