Microglia–Müller Glia Cell Interactions Control Neurotrophic Factor Production during Light-Induced Retinal Degeneration
作者： Takayuki Harada , Chikako Harada , Shinichi Kohsaka , Etsuko Wada , Kazuhiko Yoshida
DOI: 10.1523/JNEUROSCI.22-21-09228.2002
关键词: Biology 、 Neurotrophin 、 Photoreceptor cell 、 Neuroscience 、 Nerve growth factor 、 GDNF family of ligands 、 Ciliary neurotrophic factor 、 Glial cell line-derived neurotrophic factor 、 Muller glia 、 Neurotrophic factors
摘要: Activation of microglia commonly occurs in response to a wide variety pathological stimuli including trauma, axotomy, ischemia, and degeneration the CNS. In retina, prolonged or high-intensity exposure visible light leads photoreceptor cell apoptosis. such light-reared we found that activated invade degenerating layer alter expression neurotrophic factors as nerve growth factor (NGF), ciliary (CNTF), glial line-derived (GDNF). Because these modulate secondary trophic Muller cells, microglia-Muller glia interaction may contribute protection photoreceptors increase present study, demonstrate possibility functional glia-glia interactions constitute key mechanism by which microglia-derived NGF, brain-derived (BDNF), CNTF indirectly influence survival, although receptors for are absent from photoreceptors, modulating basic fibroblast (bFGF) GDNF production release glia. These observations suggest regulate glia-photoreceptor network serves factor-controlling system during retinal degeneration.
elsevier.com
sci-hub.se 参考文章(94)
T Ohashi, K Ohki, T Harada, H Matsuda, K Yoshida, Y Muraki, J Imaki, C-fos gene expression in rat retinal cells after focal retinal injury. Investigative Ophthalmology & Visual Science. ,vol. 36, pp. 251- 254 ,(1995)
David S. Papermaster, Izhak Nir, Apoptosis in Inherited Retinal Degenerations Apoptosis. pp. 15- 29 ,(1994) , 10.1007/978-1-4757-9217-1_2
T Ohashi, K Ohki, T Harada, H Matsuda, K Ono, K Yoshida, J Imaki, Cone-associated c-fos gene expression in the light-damaged rat retina. Investigative Ophthalmology & Visual Science. ,vol. 37, pp. 1250- 1255 ,(1996)
D S Papermaster, J Windle, Death at an early age. Apoptosis in inherited retinal degenerations. Investigative Ophthalmology & Visual Science. ,vol. 36, pp. 977- 983 ,(1995)
Franz Hefti, Joe G. Hollyfield, Beat Knusel, Xiaoxi Qiao, Hua Gao, Elevated mRNA expression of brain-derived neurotrophic factor in retinal ganglion cell layer after optic nerve injury Investigative Ophthalmology & Visual Science. ,vol. 38, pp. 1840- 1847 ,(1997)
A. C. Bird, N. H. V. Chong, P. J. Luthert, R. A. Alexander, L. Waters, K. C. Barnett, Repeated injections of a ciliary neurotrophic factor analogue leading to long-term photoreceptor survival in hereditary retinal degeneration. Investigative Ophthalmology & Visual Science. ,vol. 40, pp. 1298- 1305 ,(1999)
Aileen Chen, Shanta M. Kumar, Christie L. Sahley, Kenneth J. Muller, Nitric Oxide Influences Injury-Induced Microglial Migration and Accumulation in the Leech CNS The Journal of Neuroscience. ,vol. 20, pp. 1036- 1043 ,(2000) , 10.1523/JNEUROSCI.20-03-01036.2000
Adriana Di Polo, Garth M. Bray, Albert J. Aguayo, Li Cheng, Colocalization of TrkB and brain-derived neurotrophic factor proteins in green-red-sensitive cone outer segments. Investigative Ophthalmology & Visual Science. ,vol. 41, pp. 4014- 4021 ,(2000)
Peter A. Campochiaro, Karl J. Wahlin, Donald J. Zack, Ruben Adler, Neurotrophic factors cause activation of intracellular signaling pathways in Müller cells and other cells of the inner retina, but not photoreceptors. Investigative Ophthalmology & Visual Science. ,vol. 41, pp. 927- 936 ,(2000)
DM Araujo, CW Cotman, Basic FGF in astroglial, microglial, and neuronal cultures: characterization of binding sites and modulation of release by lymphokines and trophic factors. The Journal of Neuroscience. ,vol. 12, pp. 1668- 1678 ,(1992) , 10.1523/JNEUROSCI.12-05-01668.1992