Microinfusion of nefazodone into the basolateral nucleus of the amygdala enhances defensive behavior induced by NMDA stimulation of the inferior colliculus
作者： S Maisonnette , C Villela , AP Carotti , J Landeira–Fernandez
DOI: 10.1016/S0031-9384(00)00256-0
关键词: Stimulation 、 Inhibitory postsynaptic potential 、 Basal ganglia 、 NMDA receptor 、 Neuroscience 、 5-HT receptor 、 Amygdala 、 Inferior colliculus 、 Serotonin 、 Chemistry 、 Experimental and Cognitive Psychology 、 Behavioral neuroscience
摘要: The inferior colliculus is notably associated with defensive behavior. Electrical or pharmacological stimulation of the induces aversive reactions such as running and jumping. Lesion basolateral nucleus amygdala decreases threshold induced by electrical colliculus. present work examined influence microinjections nefazodone, a serotonin (5-HT2) antagonist, into on N-methyl-d-aspartate (NMDA) microinjected Rats implanted cannulae in were submitted to open-field test where behaviors observed. Results indicated that microinjection nefazodone increases responses NMDA injections This result suggests have functional relationship neural circuitry Moreover, 5-HT2 receptors located at seem play an inhibitory role stimulation.
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