Effect of bacitracin on the biodegradation of β-endorphin
作者： András Patthy , László Gráf , Ágnes Kenessey , József I. Székely , Sándor Bajusz
DOI: 10.1016/0006-291X(77)90088-2
关键词: Peptide bond 、 Exopeptidase 、 Amino acid 、 Biochemistry 、 In vivo 、 Biodegradation 、 Chemistry 、 Bacitracin 、 Cleavage (embryo) 、 Carboxypeptidase
摘要: Abstract β-endorphin was incubated with rat brain homogenate, and the amino acids released were measured by acid analysis. Phe, Leu, Tyr, Lys liberated in greatest amount indicating that cleavage of Leu77-Phe78 some Lys-X peptide bonds endopeptidases followed removal terminal residues exopeptidases are main routes degradation brain. Bacitracin considerably reduced release from its action is suggested to be due inhibition amino- carboxypeptidases. also potentiated prolonged vivo analgesic activity β-endorphin.
elsevier.com
sci-hub.se 参考文章(11)
Iversen Ll, Vale Ww, Nicoll Ra, Neurobiology of peptides. Neurosciences research program bulletin. ,vol. 16, pp. 209- 370 ,(1978)
C. Pert, A Pert, J. Chang, B. Fong, (D-Ala2)-Met-enkephalinamide: a potent, long-lasting synthetic pentapeptide analgesic Science. ,vol. 194, pp. 330- 332 ,(1976) , 10.1126/SCIENCE.968485
L. GRAF, J. I. SZEKELY, A. Z. RONAI, ZSUZSA DUNAI-KOVACS, S. BAJUSZ, Comparative study on analgesic effect of Met5-enkephalin and related lipotropin fragments. Nature. ,vol. 263, pp. 240- 242 ,(1976) , 10.1038/263240A0
J.I. Székely, A.Z. Rónai, Zsuzsa Dunai-Kovács, Erzsébet Miglécz, Ilona Berzétri, S. Bajusz, L. Gráf, (D-MET2, PRO5)-enkephalinamide: a potent morphine-like analgesic European Journal of Pharmacology. ,vol. 43, pp. 293- 294 ,(1977) , 10.1016/0014-2999(77)90032-2
Brian M. Austen, Derek G. Smyth, The NH2-terminus of C-fragment is resistant to the action of aminopeptidases. Biochemical and Biophysical Research Communications. ,vol. 76, pp. 477- 482 ,(1977) , 10.1016/0006-291X(77)90749-5
András Z. Rónai, László Gráf, József I. Székely, Zsuzsa Dunai-Kovács, Sándor Bajusz, Differential behaviour of LPH-(61–91)-peptide in different model systems: Comparison of the opioid activities of LPH-(61–91)-peptide and its fragments FEBS Letters. ,vol. 74, pp. 182- 184 ,(1977) , 10.1016/0014-5793(77)80842-9
Richard J. Miller, K.-J. Chang, Pedro Cuatrecasas, Sam Wilkinson, The metabolic stability of the enkephalins. Biochemical and Biophysical Research Communications. ,vol. 74, pp. 1311- 1317 ,(1977) , 10.1016/0006-291X(77)90585-X
JEAN M. HAMBROOK, BARRY A. MORGAN, MICHAEL J. RANCE, COLIN F. C. SMITH, Mode of deactivation of the enkephalins by rat and human plasma and rat brain homogenates. Nature. ,vol. 262, pp. 782- 783 ,(1976) , 10.1038/262782A0
László Gráf, Ágnes Kenessey, Specific cleavage of a single peptide bond (residues 77-78) in β-lipotropin by a pituitary endopeptidase FEBS Letters. ,vol. 69, pp. 255- 260 ,(1976) , 10.1016/0014-5793(76)80699-0
B DESBUQUOIS, F KRUG, P CUATRECASAS, Inhibitors of glucagon inactivation. Effect on glucagon--receptor interactions and glucagon-stimulated adenylate cyclase activity in liver cell membranes. Biochimica et Biophysica Acta. ,vol. 343, pp. 101- 120 ,(1974) , 10.1016/0304-4165(74)90242-6