Predicting the need for insulin therapy in late onset (40-69 years) diabetes mellitus

作者: T. J. Lyons , L. Kennedy , A. B. Atkinson , K. D. Buchanan , D. R. Hadden

DOI: 10.1111/J.1464-5491.1984.TB01938.X

关键词: GastroenterologyMedicineNewly diagnosedInternal medicineBody weightInsulinDiabetes mellitusGlucose tolerance testProspective cohort studyEndocrinologyInsulin responseLate onset

摘要: A six-year prospective study of 144 newly diagnosed, symptomatic diabetic patients aged 40-69 years showed that 21 (15%) required insulin therapy, commencing 1-61 months after diagnosis. The plasma response to oral glucose was assessed at the time All 12 with very low peak (less than or equal 6 mU/l) therapy. Thirty-six had an intermediate (greater less 18 mU/l); these, 7 a mean weight 88% (range 73-96%) average body insulin, while 29 117% 98-158%) weight, did not. Ninety-six 2 whose weights were 96% and 100% remainder Consideration initial provides useful prediction eventual need for insulin.

参考文章(8)
D L Horwitz, J I Starr, M E Mako, W G Blackard, A H Rubenstein, Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood. Journal of Clinical Investigation. ,vol. 55, pp. 1278- 1283 ,(1975) , 10.1172/JCI108047
S. Srikanta, Om P. Ganda, George S. Eisenbarth, J. Stuart Soeldner, Islet-cell antibodies and beta-cell function in monozygotic triplets and twins initially discordant for Type I diabetes mellitus. The New England Journal of Medicine. ,vol. 308, pp. 322- 325 ,(1983) , 10.1056/NEJM198302103080607
H. Keen, S. Ng Tang Fui, 1 The definition and classification of diabetes mellitus Clinics in Endocrinology and Metabolism. ,vol. 11, pp. 279- 305 ,(1982) , 10.1016/S0300-595X(82)80017-0
H. Keen, R. J. Jarrett, K. G. M. M. Alberti, Diabetes mellitus: a new look at diagnostic criteria. Diabetologia. ,vol. 16, pp. 283- 285 ,(1979) , 10.1007/BF01223616
D R Hadden, D A Montgomery, R J Skelly, E R Trimble, J A Weaver, E A Wilson, K D Buchanan, Maturity onset diabetes mellitus: response to intensive dietary management. BMJ. ,vol. 3, pp. 276- 278 ,(1975) , 10.1136/BMJ.3.5978.276
David R. Hadden, E. Anne Wilson, Dietary management of diabetes mellitus Proceedings of the Nutrition Society. ,vol. 40, pp. 247- 255 ,(1981) , 10.1079/PNS19810035
Mc Carroll, Insulin clearance by the isolated perfused rat liver. Queens University Belfast. ,(1971)