Association between the ratio of serum arachidonic acid to eicosapentaenoic acid and the presence of depressive symptoms in a general Japanese population: the Hisayama Study.

摘要: Abstract Background Epidemiological evidence suggests that fish consumption and intake of n-3 polyunsaturated fatty acids (PUFA)—namely, eicosapentaenoic acid (EPA) docosahexaenoic (DHA)—confer protection against depression. However, few studies have addressed the influence balance between PUFA n-6 in human body on Methods A total 2,529 community-dwelling Japanese residents aged ≥ 40 years were assessed for depressive symptoms (defined as a score 16 points or more Center Epidemiologic Studies Depression Scale [CES-D]) 2007. The serum arachidonic (AA) /EPA ratio AA/DHA measured frozen samples collected 2002 categorized into quartiles. odds ratios (ORs) presence calculated using logistic regression model. Results prevalence was 4.3%. There no significant association either AA/EPA symptoms. subjects with highest (range: 3.28–13.3) had 4.10 times (95%CI: 1.13–19.80) greater OR than those lowest (0.30–1.65) after adjusting confounding factors subgroup high-sensitivity C-reactive protein (hs-CRP) ≥ 1.0 mg/L, while clear observed hs-CRP  Limitations Reverse causality is possible due to cross-sectional study design. Conclusions Our findings suggest higher associated likelihood systemic inflammation general population.