Plasma clearances of branched-chain amino acids in control subjects and in patients with cirrhosis
作者： G. Marchesini , G.P. Bianchi , H. Vilstrup , G.A. Checchia , Daniela Patrono
DOI: 10.1016/S0168-8278(87)80017-X
关键词: Cirrhosis 、 Basal (phylogenetics) 、 Valine 、 Decreased Concentration 、 Internal medicine 、 Pathogenesis 、 Amino acid 、 Endocrinology 、 Leucine 、 Chemistry 、 Isoleucine 、 Hepatology
摘要: Summary In an attempt to clarify the pathogenesis of decreased branched-chain amino acid (BCAA) plasma concentrations in cirrhosis, clearances were measured 7 patients with cirrhosis and age- sex-matched control subjects. BCAA given as prime-continuous infusions. The valine, isoleucine, leucine, calculated infusion rate divided by steady state concentration, low normal cirrhotics despite hyperinsulinaemia, but different had ( P endogenous basal appearance rates BCAA, estimated multiplied clearances, lower concentration (394 ± 81 μmol/l (mean SD) present series vs 510 68 controls;
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