Cyclin D1 and p21WAF1/CIP1 in ulcerative colitis-related inflammation and epithelial neoplasia: a study of aberrant expression and underlying mechanisms
作者： Newton A.C.S Wong , Nicholas J Mayer , Catriona E Anderson , Honora C Mckenzie , Robert G Morris
DOI: 10.1016/S0046-8177(03)00125-4
关键词: Cancer research 、 Tumor progression 、 Immunostaining 、 Cyclin D1 、 Carcinogenesis 、 Carcinoma 、 Biology 、 Cell cycle 、 Immunohistochemistry 、 Dysplasia
摘要: It is unclear whether and how cyclin D1 and/or p21(WAF1/CIP1) dysregulation contribute to ulcerative colitis (UC)-related inflammation colorectal carcinogenesis. Cases of quiescent UC (QUC; n = 15), active (AUC; 23), UC-related dysplasia (n 35) adenocarcinomas (CRCs; 11) were studied with immunohistochemistry. The CRCs also beta-catenin, bcl2, p53 immunohistochemistry, k-ras mutation analyses, gene fluorescence in situ hybridization. QUC showed (negative/weak staining) (surface epithelial upper-third crypt expression similar that normal colorectum. Moderate or strong immunostaining was seen 9% AUC cases, 40% 36% CRCs. Although these carcinomas neither amplification nor any association between overexpression, the latter closely related nuclear beta-catenin expression. Increased lower-third staining 57% cases; decreased staining, 23% absent weak 55% change always associated but could not be bcl2 In conclusion, shows up-regulated Cyclin up-regulation down-regulation occur early less common than sporadic CRCs, signaling. at an equal higher frequency among compared attributable mutation.
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