Exploring the epidemiological characteristics of cancers of unknown primary site in an Australian population: implications for research and clinical care.

摘要: Objectives: To investigate incidence, mortality and case survival trends for cancer of unknown primary site (CUP) consider clinical implications. Method: South Australian Cancer Registry data were used to calculate age-standardised incidence rates from 1977 2004. Disease-specific survivals, socio-demographic, histological secular predictors CUP, compared with cancers known site, CUP types, using multivariable logistic regression investigated. Results: Incidence increased approximately 60% between 1977-80 1981-84. Rates peaked in 1993-96. Male female rate ratios approximated 1.3:1. age. The odds unspecified type, the more common adenocarcinomas, higher males than females, non-metropolitan residents, low socio-economic areas, 1977-88 subsequent diagnostic periods. represented a proportion Indigenous patients. Case was 7% at 10 years diagnosis. Factors predictive lower included older age, male sex, status, histology type. Conclusion: Results point poor outcomes, but modest improvement survival. study identifies socio-demographic groups elevated risk worse treatment outcomes where research attention are required.