Targeting SRC coactivators blocks the tumor-initiating capacity of cancer stem-like cells
作者： Aarti D. Rohira , Fei Yan , Lei Wang , Jin Wang , Suoling Zhou
DOI: 10.1158/0008-5472.CAN-16-2982
关键词: Cancer cell 、 Cancer research 、 Population 、 Nuclear receptor coactivator 3 、 Biology 、 Metastasis 、 Tumor initiation 、 Immunology 、 Epithelial–mesenchymal transition 、 Cancer 、 Stem cell marker
摘要: Tumor-initiating cells (TIC) represent cancer stem-like cell (CSC) subpopulations within tumors that are thought to give rise recurrent after therapy. Identifying key regulators of TIC/CSC maintenance is essential for the development therapeutics designed limit recurrence. The steroid receptor coactivator 3 (SRC-3) overexpressed in a wide range cancers, driving tumor initiation, proliferation, and metastasis. Here we report SRC-3 supports state induces an epithelial-to-mesenchymal transition (EMT) by expression master EMT stem markers. We also show inhibition SRC-1 with SI-2, second-generation SRC-3/SRC-1 small-molecule inhibitor, targets CSC/TIC population both vitro vivo Collectively, these results identify SRC coactivators as capacity can serve potential therapeutic prevent recurrence cancer. Cancer Res; 77(16); 4293-304. ©2017 AACR.
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