Double-Blind, Placebo-Controlled Immunotherapy with a High-Molecular-Weight, Formalinized Allergoid in Grass Pollen Allergy

作者: Jean Bousquet , Edda Frank , Michel Soussana , Adnan Hejjaoui , Hans J. Maasch

DOI: 10.1159/000234277

关键词: ImmunologyPollenImmunotherapyNasal provocation testSpecific iggDouble blindPlaceboAllergoidBiologyGrass pollen allergy

摘要: Specific immunotherapy is effective in grass pollen allergy with standardized extracts and formalinized allergoids; but systemic reactions are not uncommon. A high-molecular-weight (greater than 85,000 daltons), allergoid was investigated a double-blind, placebo-controlled study to assess its safety efficacy. Twenty patients received placebo 39 the using rather aggressive protocol. Five developed mild transient reaction high doses of one had more severe requiring treatment. Nasal challenges performed orchard grains showed that threshold number eliciting nasal symptoms significantly (p less 0.01) greater treated group. This group during season specific IgG levels were elevated. There significant correlation between no symptoms. dose-dependent effect allergoids.

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