Myeloid Cell Origins, Differentiation, and Clinical Implications

摘要: The hematopoietic stem cell (HSC) is a multipotent that resides in the bone marrow and has ability to form all of cells blood immune system. Since its first purification 1988, additional studies have refined phenotype functionality HSCs characterized their downstream progeny. lineage divided into two main branches: myeloid lymphoid arms. arm by common progenitor resulting types. stages hematopoiesis been defined both mice humans. During embryological development, earliest takes place yolk sac islands then migrates fetal liver organs. Some adult populations develop directly from progenitors without apparent intermediates, such as tissue-resident macrophages. Hematopoiesis also changes over time, with bias dominating toward development animals age. Defects myelopoiesis contribute many hematologic disorders, some these can be overcome therapies target aberrant stage development. Furthermore, insights informed us mechanisms programmed removal. CD47/SIRPα axis, myeloid-specific checkpoint, limits macrophage removal but exploited solid malignancies. Therapeutics targeting CD47 represent new strategy for treating cancer. Overall, an understanding implications regenerative medicine, transplantation, malignancy, other diseases.