Advances in pancreatic cancer research: Moving towards early detection

摘要: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms cancer. Substantial progress has been made in understanding biology pancreatic cancer, and advances patient management have significant. However, patients (nearly 80%) who present with locally advanced or metastatic disease an extremely poor prognosis. Survival better for those malignant localized to pancreas, because surgical resection at offers only chance cure. Therefore, early detection cancer may benefit PDAC. its low rate incidence limitations current screening strategies make difficult. Recent pathogenesis PDAC suggest that it possible detect stages even identify precursor lesions. The presence new-onset diabetes mellitus phase provide clues diagnosis. Advances identification novel circulating biomarkers including serological signatures, autoantibodies, epigenetic markers, tumor cells microRNAs they can be used as potential tools precursors stage future. proper based on effective methodologies need tested clinical application.