Circulating Epithelial Cells in Patients with Pancreatic Lesions: Clinical and Pathologic Findings

摘要: Background Circulating epithelial cell (CEC) isolation has provided diagnostic and prognostic information for a variety of cancers, previously supporting their identity as circulating tumor cells in the literature. However, we report CEC findings patients with benign, premalignant, malignant pancreatic lesions using size-selective filtration device. Study Design Peripheral blood samples were drawn from found to have on preoperative imaging at surgical clinic. Blood was filtered ScreenCell devices, which evaluated microscopically by cytopathologist. Pathologic data clinical outcomes these obtained medical records during 1-year follow-up period. Results Nine healthy volunteers formed control group be negative CECs. There 179 that study cohort. morphologically similar lesions. Specifically, CECs identified 51 105 ductal adenocarcinomas (49%), 7 11 neuroendocrine tumors (64%), 13 21 intraductal papillary mucinous neoplasms (62%), 6 chronic pancreatitis. Rates identification (p = 0.41). In addition, adenocarcinoma not associated poor prognosis. Conclusions Although volunteers, they The presence presenting is neither malignancy nor adenocarcinoma.