Blood fibrinogen levels discriminate low- and high-risk intraductal papillary mucinous neoplasms (IPMNs).

摘要: Abstract Backround The risk assessment of intraductal papillary mucinous neoplasms (IPMN) to either guide patients surgical resection or watchful waiting is still under debate. Additional markers better separate low and high-risk lesions would improve patient selection. Methods Patients who underwent pancreatic resections for IPMNs between January 2008 December 2012 with available blood samples were selected retrospectively assessed. Data on cyst characteristics such as size, duct relation main-duct dilatation collected plasma fibrinogen levels measured. Results A total 73 fulfilled the inclusion criteria by pathologically confirmed IPMN sample. Histologically, classified low-grade borderline in 52 (71.2%, group 1) high-grade invasive 21 (28.8%, 2) all cases. Fibrinogen showed significant differences two groups (group 1: mean 3.62 g/L (SD ± 1.14); 2: 4.49 g/L (SD ± 1.57); p = 0.027). ROC-curve analysis calculated cut-off value 4.71 g/L separated 1 2 (p = 0.008). remained only factor multivariable analysis, size not significant. Conclusion Blood differed high therefore, use an additional discriminator pre-operative should be further evaluated.