Fast clonal expansion and limited neural stem cell self-renewal in the adult subependymal zone
作者： Filippo Calzolari , Julia Michel , Emily Violette Baumgart , Fabian Theis , Magdalena Götz
DOI: 10.1038/NN.3963
关键词: Neurogenesis 、 Lateral ventricles 、 Self renewal 、 Subependymal zone 、 Neuroscience 、 Cell growth 、 Ependyma 、 Biology 、 Neural stem cell 、 Olfactory bulb
摘要: We analyzed the progeny of individual neural stem cells (NSCs) mouse adult subependymal zone (SEZ) in vivo and found a markedly fast lineage amplification, as well limited NSC self-renewal exhaustion few weeks. further unraveled mechanisms neuronal subtype generation, finding that higher proportion NSCs were dedicated to generate deep granule olfactory bulb larger clones produced by these NSCs.
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