Confirmation of chromosome 9p linkage in familial melanoma

摘要: Malignant melanoma occurs as a familial cancer in 5%-10% of cases where it segregates manner consistent with autosomal dominant inheritance. Evidence from cytogenetics, fine-mapping studies deletions melanomas, and recent linkage supports the location human predisposition gene on short arm chromosome 9. The authors have carried out analysis using 9p markers IFNA D9S126 26 Australian kindreds. Multipoint gave peak lod score 4.43, 15 cM centromeric to D9S126, although 4.13 was also found telomeric IFNA. These data confirm existence susceptibility indicate that this locus most probably lies outside IFNA-D9S126 interval. No significant heterogeneity between families, when either pairwise or multipoint were analyzed HOMOG. 25 refs., 1 fig., 3 tabs.