The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development

作者: Richard Grose , Vera Fantl , Sabine Werner , Athina-Myrto Chioni , Monika Jarosz

DOI: 10.1038/SJ.EMBOJ.7601583

关键词: CytokineEndocrinologyInterleukin 18Cancer researchBiologyFibroblast growth factor receptor 2Keratin 5Fibroblast Growth Factor Receptor 2bReceptor tyrosine kinaseInternal medicineFibroblast growth factorCell

摘要: … Fgfr2b in post-natal skin development and in adult skin homeostasis. Mice lacking … skin, with increased numbers of macrophages and γδT cells with abnormal morphology. Mutant skin …

参考文章(38)
Wallace L. McKeehan, Norman M. Greenberg, Barbara Foster, Michael M. Ittmann, Fen Wang, Kerstin McKeehan, Wei Guo, Scot Jauma, Chengliu Jin, Cooperation between Ectopic FGFR1 and Depression of FGFR2 in Induction of Prostatic Intraepithelial Neoplasia in the Mouse Prostate Cancer Research. ,vol. 63, pp. 8784- 8790 ,(2003)
Keisuke Sekine, Hideyo Ohuchi, Masanori Fujiwara, Masahiro Yamasaki, Tatsuya Yoshizawa, Takashi Sato, Naoko Yagishita, Daisuke Matsui, Yoshihiko Koga, Nobuyuki Itoh, Shigeaki Kato, Fgf10 is essential for limb and lung formation Nature Genetics. ,vol. 21, pp. 138- 141 ,(1999) , 10.1038/5096
J. Jameson, A role for skin gammadelta T cells in wound repair. Science. ,vol. 296, pp. 747- 749 ,(2002) , 10.1126/SCIENCE.1069639
M. Girardi, Regulation of Cutaneous Malignancy by gamma delta T Cells Science. ,vol. 294, pp. 605- 609 ,(2001) , 10.1126/SCIENCE.1063916
M Hajihosseini, B Spencer-Dene, C Dickson, L De Moerlooze, I Rosewell, J M Revest, An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis Development. ,vol. 127, pp. 483- 492 ,(2000) , 10.1242/DEV.127.3.483
Isabelle Bernard-Pierrot, David Ricol, Andrew Cassidy, Alexander Graham, Paul Elvin, Aurélie Caillault, Séverine Lair, Philippe Broët, Jean-Paul Thiery, François Radvanyi, Inhibition of human bladder tumour cell growth by fibroblast growth factor receptor 2b is independent of its kinase activity. Involvement of the carboxy-terminal region of the receptor. Oncogene. ,vol. 23, pp. 9201- 9211 ,(2004) , 10.1038/SJ.ONC.1208150
H. Min, D. M. Danilenko, S. A. Scully, B. Bolon, B. D. Ring, J. E. Tarpley, M. DeRose, W. S. Simonet, Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless Genes & Development. ,vol. 12, pp. 3156- 3161 ,(1998) , 10.1101/GAD.12.20.3156