Gliotransmitters and cytokines in the control of blood-brain barrier permeability.
作者： Elena D. Osipova , Oxana V. Semyachkina-Glushkovskaya , Andrey V. Morgun , Natalia V. Pisareva , Natalia A. Malinovskaya
DOI: 10.1515/REVNEURO-2017-0092
关键词: Microglia 、 Pannexin 、 Cell biology 、 Microvesicles 、 Angiogenesis 、 Pericyte 、 Blood–brain barrier 、 Neuroinflammation 、 Astrocyte
摘要: The contribution of astrocytes and microglia to the regulation neuroplasticity or neurovascular unit (NVU) is based on coordinated secretion gliotransmitters cytokines release uptake metabolites. Blood-brain barrier (BBB) integrity angiogenesis are influenced by perivascular cells contacting with abluminal side brain microvessel endothelial (pericytes, astrocytes) immune existing (microglia) invading NVU (macrophages) under pathologic conditions. activated astroglial microglial provided distinct mechanisms, affects intercellular communication, results in establishment microenvironment controlling BBB permeability neuroinflammation. Glial glutamate transporters connexin pannexin hemichannels working tight functional coupling purinergic system serve as promising molecular targets for manipulating communications that control pathologies associated excessive angiogenesis, cerebrovascular remodeling, BBB-mediated Substantial progress deciphering mechanisms underlying (patho)physiology glia provides approaches novel clinically relevant therapies disorders. present review summarizes current understandings secretory machinery expressed glial (glutamate transporters, hemichannels, exocytosis membrane-derived microvesicles, inflammasomes) role secreted (patho)physiologic
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