Endometrial receptivity: expression of alpha3beta1, alpha4beta1 and alphaVbeta1 endometrial integrins in women with impaired fertility.

摘要: Advances in immunohistochemical methods with the specificity of poly- and monoclonal antibodies allow description endometrial receptivity, which is characterized by ability secretion phase specific proteins glikoproteins epithelial stromal cells. We studied differences expression alpha3beta1, alpha4beta1 alphaVbeta1 integrins endometrium women recurrent miscarriages unexplained infertility. The tissue was collected during hysteroscopy performed between 7th 9th day after ovulation. evaluation integrin determined all biopsies. Staining intensity alpha3beta1 glandular epithelium stroma similar both groups. In we noted a lower concentrations midluteal than Moreover, were expressed more frequently infertility those miscarriages. However, alphaV(2)1 staining stronger that alpha4beta1. It can be concluded, these may play an important role implantation process.