A radical mediated approach to the stereoselective formal total synthesis of (+)-Sch 642305
作者： Tushar Kanti Chakraborty , Rajarshi Samanta , Pulukuri Kiran Kumar , None
DOI: 10.1016/J.TET.2009.06.059
关键词: Chemical synthesis 、 Hydroxymethyl 、 Stereochemistry 、 Synthon 、 Stereoselectivity 、 Total synthesis 、 Double bond 、 Epoxide 、 Chemistry 、 Ring (chemistry) 、 Organic chemistry 、 Biochemistry 、 Drug discovery
摘要: A formal total synthesis of (+)-Sch-642305 is described. The synthesis, which commenced from a simple chiral synthon (5S)-5-(hydroxymethyl)dihydrofuran-2(3H)-one, employed, as key step, radical mediated opening epoxy alcohol intermediate with Cp 2 Ti(III)Cl following an efficient method developed by us earlier. resultant was intramolecularly trapped the electron deficient double bond present in molecule to give rise its highly functionalized six-membered carbocyclic ring stereoselective manner.
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