Stereoselective synthesis of the bacterial DNA primase inhibitor Sch 642305 and its C-4 epimer
作者： Jorge García-Fortanet , Miguel Carda , J. Alberto Marco
DOI: 10.1016/J.TET.2007.09.080
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摘要: Abstract A convergent stereoselective synthesis of the bacterial DNA primase inhibitor Sch 642305 and its non-natural epimer at C-4 is described. key aspect was construction a trans-2,3-disubstituted cyclohexanone system by means Michael addition/α-alkylation sequence. The macrolactone ring either stereoisomer created using Mitsunobu Yamaguchi procedures, respectively.
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