Imaging Lenticular Autofluorescence in Older Subjects.

摘要: Purpose: To evaluate whether a practical method of imaging lenticular autofluorescence (AF) can provide an individualized measure correlated with age-related lens yellowing in older subjects undergoing tests involving shorter wavelength lights. Methods: Lenticular AF was imaged 488-nm excitation using confocal scanning laser ophthalmoscope (cSLO) routinely used for retinal imaging. There were 75 (ages 47-87) at two sites; small cohort younger served as controls. At one site, the cSLO equipped internal reference to allow quantitative measurements; other reduced-illuminance (RAFI) used. In subset subjects, density index independently estimated from dark-adapted spectral sensitivities performed psychophysically. Results: intensity significantly higher eyes than when measured (59.2 ± 15.4 vs. 134.4 31.7 gray levels; P < 0.05) well recorded RAFI without (10.9 1.5 26.1 5.7 0.05). positively age; however, there could also be large differences between individuals similar age. indices psychophysical measures. Conclusions: and yellowing, may good candidate distinguish preretinal deficits short-wavelength lights eyes.