UPLC-MS/MS quantitative analysis and structural fragmentation study of five Parmotrema lichens from the Eastern Ghats.
作者： K. Kumar , Bandi Siva , V.U.M. Sarma , Satish Mohabe , A. Madhusudana Reddy
DOI: 10.1016/J.JPBA.2018.04.017
关键词: Selected reaction monitoring 、 Phytochemical 、 Chemistry 、 Lichen 、 Parmotrema 、 Uplc ms ms 、 Fragmentation (cell biology) 、 ABTS 、 Quantitative analysis (chemistry) 、 Chromatography
摘要: Comparative phytochemical analysis of five lichen species [Parmotrema tinctorum (Delise ex Nyl.) Hale, P. andinum (Mull. Arg.) praesorediosum (Nyl.) grayanum (Hue) austrosinense (Zahlbr.) Hale] Parmotrema genus were performed using two complementary UPLC-MS systems. The first system consists high resolution UPLC-QToF-MS/MS spectrometer and the second consisted UPLC-MS/MS in Multiple Reaction Monitoring (MRM) mode for quantitative major constituents selected species. individual compounds (47 compounds) identified Q-ToF-MS/MS, via comparison exact molecular masses from their MS/MS spectra, literature data retention times to those standard which isolated crude extract abundant lichen, tinctorum. also allowed us identify unknown peaks/compounds, further characterized by mass fragmentation studies. MRM was useful have a better discrimination according chemical profile. Moreover, determination antioxidant activities (ABTS+ inhibition) Advance Glycation Endproducts (AGEs) inhibition carried out extracts revealed potential antiglycaemic activity be confirmed austrosinense.
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