Tolfenamic Acid and Migraine-Aspects on Prostaglandins and Leukotrienes

摘要: Migraine is a paroxysmal disorder characterized by recurrent attacks of headache, with or without associated visual and gastrointestinal disturbances. can be classified in two main groups, common classic. Theories trying to explain the pathogenesis migraine attack may emphasize either central peripheral aspects disease. The vascular theory stress importance blood flow both. Cerebral vasoconstriction early phases followed vasodilatation pain. Biochemical mediators responses are not exactly known, but platelets 5-hydroxytryptamine thromboxane released from them as well noradrenaline potent vasoconstrictors, while kinins prostaglandins vasodilatory phase attacks. This review presents evidence for role arachidonic acid metabolites, leukotrienes migraine. comes measurements eicosanoids biological fluids during after attack, infusion studies where mimic migraneous symptoms, good effect non-steroidal anti-inflammatory drugs treatment prophylaxis Additional data based on experimental biochemical which catecholamines indolamines have been shown increase synthesis prostaglandins. However, final still awaits its confirmation.