作者: Emmanuel J. Favaloro , Giuseppe Lippi , Massimo Franchini
关键词: PFA-100 、 Platelet 、 Von Willebrand disease 、 Bleeding diathesis 、 Hemostasis 、 Bioinformatics 、 Function (biology) 、 Platelet aggregation 、 Genetic testing 、 Medicine
摘要: Defects in primary hemostasis typically lead to a bleeding diathesis and include several disorders, such as von Willebrand disease various platelet function defects that may arise because of failure membrane receptors, deficiencies internal storage organelles, and/or signal transduction problems. The laboratory identification defect including now involves multi-step process. These processes begin with full blood count assess size, progressing, if necessary, aggregation studies, leading further specific testing flow cytometry, electron micro-scopy genetic testing. This review outlines the sequential process investigations, discusses each essential components some detail.