Contemporary platelet function testing.

作者: Emmanuel J. Favaloro , Giuseppe Lippi , Massimo Franchini

DOI: 10.1515/CCLM.2010.121

关键词: PFA-100PlateletVon Willebrand diseaseBleeding diathesisHemostasisBioinformaticsFunction (biology)Platelet aggregationGenetic testingMedicine

摘要: Defects in primary hemostasis typically lead to a bleeding diathesis and include several disorders, such as von Willebrand disease various platelet function defects that may arise because of failure membrane receptors, deficiencies internal storage organelles, and/or signal transduction problems. The laboratory identification defect including now involves multi-step process. These processes begin with full blood count assess size, progressing, if necessary, aggregation studies, leading further specific testing flow cytometry, electron micro-scopy genetic testing. This review outlines the sequential process investigations, discusses each essential components some detail.

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