Heart rate complexity in sinoaortic-denervated mice.

摘要: New Findings What is the central question of this study? New measurements for cardiovascular complexity, such as detrended fluctuation analysis (DFA) and multiscale entropy (MSE), have been shown to predict outcomes. Given that diseases are accompanied by autonomic imbalance decreased baroreflex sensitivity, is: do baroreceptors contribute complexity? What main finding its importance? Sinoaortic denervation altered both DFA scaling exponents MSE, indicating short- long-term mechanisms complexity in sinoaortic denervated mice, resulting a loss physiological complexity. These results suggest key element complex structures involved heart rate variability regulation. Recently, (HR) oscillations recognized behaviours derived from non-linear processes. Physiological theory based on idea healthy systems present high i.e. non-linear, fractal at multiple scales, with long-range correlations. The (HRV) has adverse Based most decrease we hypothesize plays an important role behaviour. Mice had subjected (SAD) were implanted catheters femoral artery jugular vein 5 days prior experiment. After recording baseline arterial pressure (AP), pulse interval time series generated intervals between consecutive values diastolic pressure. HRV was determined using entropy. α1 exponent (a short-term index) remarkably SAD mice (0.79 ± 0.06 versus 1.13 ± 0.04 control mice), whereas slightly increased α2 index; 1.12 ± 0.03 1.04 ± 0.02 mice). In total (13.2 ± 1.3) compared (18.9 ± 1.4). conclusion, regularity affecting suggesting play considerable structure HRV.