Baroreceptor denervation reduces inflammatory status and worsens cardiovascular collapse during systemic inflammation

作者: Mateus R Amorim , Júnia L de Deus , Camila A Pereira , Luiz EV da Silva , Gabriela S Borges

DOI: 10.1101/748608

关键词:

摘要: Beyond the regulation of cardiovascular function, baroreceptor afferents play polymodal roles. We hypothesized that denervation affects lipopolysaccharide (LPS)-induced systemic inflammation (SI) and hemodynamic collapse in conscious rats, these parameters are interconnected. combine: a) thermoregulatory recordings after LPS administration at a septic-like dose b) analysis complexity, c) evaluation vascular function mesenteric resistance vessels, d) measurements inflammatory cytokines (plasma spleen). LPS-induced drop blood pressure was higher sino-aortic denervated (SAD) rats. associated with SAD-dependent autonomic disbalance. dysfunction not affected by SAD. Surprisingly, SAD blunted surges plasma spleen cytokines. These data indicate key to alleviate collapse, affecting control, without vessels. Moreover, baroreflex modulation SI seem be

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